A 9-week pregnancy is being terminated medically. The standard regimen for medical abortion up to 9 weeks per WHO guidelines is:

• A Misoprostol 400 µg orally every 4 hours for 3 doses
• B Mifepristone 600 mg orally followed by misoprostol 400 µg orally after 48 hours
• C Methotrexate 50 mg/m² IM followed by misoprostol 800 µg vaginally after 5 days
• D Mifepristone 200 mg orally followed by misoprostol 800 µg vaginally or sublingually after 24–48 hours ✓

Explanation

WHO and standard protocols for medical abortion up to 12 weeks: mifepristone 200 mg orally (not 600 mg — 200 mg is equally effective) followed 24–48 hours later by misoprostol 800 µg vaginally, sublingually, or buccally. This combination achieves 95–98% complete abortion rate. Misoprostol alone is less effective. Mifepristone 600 mg is no longer recommended as 200 mg has equivalent efficacy. Methotrexate-misoprostol is a less common regimen with lower efficacy.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

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Written and medically reviewed by the StethoPrep medical team.