A 10-week intrauterine pregnancy is confirmed on ultrasound. Medical termination using mifepristone + misoprostol regimen is requested. The standard WHO-recommended outpatient regimen is:

• A Misoprostol 400 μg orally repeated every 4 hours for 3 doses
• B Mifepristone 200 mg orally, followed 24–48 hours later by misoprostol 800 μg vaginally/sublingually ✓
• C Mifepristone 600 mg orally, followed 72 hours later by misoprostol 400 μg orally
• D Methotrexate 50 mg/m² IM followed by misoprostol 800 μg vaginally 5–7 days later

Explanation

The WHO-recommended regimen for medical abortion up to 12 weeks is mifepristone 200 mg orally, followed 24–48 hours later by misoprostol 800 μg administered vaginally, sublingually, or buccally. The older regimen used mifepristone 600 mg but 200 mg is equally effective. Methotrexate+misoprostol is used when mifepristone is unavailable. Misoprostol-alone regimens are less effective than combination therapy.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.