A patient at 9 weeks gestation requests medical termination. She has no contraindications. The WHO-recommended regimen for medical abortion at this gestation is:

• A Mifepristone 200 mg orally followed by misoprostol 800 mcg 24–48 hours later ✓
• B Misoprostol 800 mcg vaginally alone
• C Methotrexate 50 mg/m² IM followed by misoprostol 800 mcg 3–7 days later
• D Mifepristone 600 mg orally followed by misoprostol 400 mcg 48 hours later

Explanation

WHO guidelines recommend mifepristone 200 mg orally followed 24–48 hours later by misoprostol 800 mcg sublingually or vaginally for medical abortion up to 12 weeks. The 200 mg dose is equally effective as 600 mg with fewer side effects. The combination achieves >95% complete abortion rate. Misoprostol-alone regimens have lower efficacy and are used when mifepristone is unavailable.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

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Written and medically reviewed by the StethoPrep medical team.