The recommended regimen for medical abortion up to 63 days (9 weeks) of gestation as per WHO 2022 guidelines is:

• A Mifepristone 600 mg orally followed by misoprostol 400 µg orally 24 hours later
• B Mifepristone 200 mg orally followed by misoprostol 800 µg vaginally/sublingually 24–48 hours later ✓
• C Misoprostol 800 µg sublingually alone repeated every 3 hours for three doses
• D Mifepristone 200 mg followed by misoprostol 400 µg sublingually 48 hours later

Explanation

WHO 2022 recommends mifepristone 200 mg orally followed 24–48 hours later by misoprostol 800 µg administered vaginally, sublingually, or buccally for medical abortion up to 63 days. The 200 mg dose is as effective as 600 mg and minimises cost. Sublingual route has higher bioavailability but more GI side effects. Misoprostol-alone regimens are less effective and are used only when mifepristone is unavailable.

Reference: Williams Obstetrics, 26th ed.

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Written and medically reviewed by the StethoPrep medical team.