A woman at 9 weeks gestation requests medical termination. The recommended mifepristone-misoprostol regimen approved by WHO for complete medical abortion up to 70 days is:

• A Mifepristone 600 mg oral, then misoprostol 400 mcg oral 24 hours later
• B Misoprostol 800 mcg vaginal alone, repeated every 3 hours up to 3 doses
• C Mifepristone 200 mg, then methotrexate 50 mg/m² IM
• D Mifepristone 200 mg oral, then misoprostol 800 mcg sublingual/vaginal 24–48 hours later ✓

Explanation

WHO 2022 guidelines recommend mifepristone 200 mg orally followed 24–48 hours later by misoprostol 800 mcg sublingually, buccally, or vaginally for medical abortion up to 70 days (10 weeks). The lower 200 mg mifepristone dose is as effective as 600 mg. Misoprostol-alone regimens have lower efficacy. Mifepristone-methotrexate is rarely used and not standard. This regimen achieves complete abortion in >95% of cases.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

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Written and medically reviewed by the StethoPrep medical team.