A team of soldiers is deployed for jungle warfare training in a leptospirosis-endemic district during the monsoon. Which regimen is recommended for chemoprophylaxis against leptospirosis?
- A Penicillin G 1.2 million units IM monthly
- B Doxycycline 200 mg orally once weekly ✓
- C Azithromycin 500 mg orally once weekly
- D Ciprofloxacin 500 mg orally twice daily
Correct answer: B. Doxycycline 200 mg orally once weekly
Explanation
Doxycycline 200 mg taken once weekly is the established chemoprophylactic regimen for short-term, high-risk exposure to leptospirosis, studied in military personnel and shown to reduce clinical disease. It is also the treatment of choice for established infection, given as penicillin G or ceftriaxone alternatives for severe disease. Azithromycin is reserved for pregnant patients and children who cannot receive tetracyclines. Fluoroquinolones have no prophylactic role here.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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