A 28-year-old woman is diagnosed with uncomplicated genital Chlamydia trachomatis infection by NAAT. She is not pregnant. According to current CDC and WHO guidelines, what is the recommended first-line treatment?

• A Azithromycin 1 g orally single dose
• B Doxycycline 100 mg orally twice daily for 7 days ✓
• C Levofloxacin 500 mg orally once daily for 7 days
• D Erythromycin base 500 mg orally four times daily for 7 days

Explanation

Current CDC guidelines recommend doxycycline 100 mg orally twice daily for 7 days as the preferred regimen for uncomplicated genital chlamydial infection in nonpregnant adults, based on superior efficacy demonstrated in rectal infection and comparable efficacy in urogenital infection. Azithromycin 1 g single dose is an alternative regimen but is no longer preferred. NACO guidelines in India also recommend doxycycline as first-line for chlamydial infections.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

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Written and medically reviewed by the StethoPrep medical team.