Which statement regarding the natural history of serologic markers in untreated syphilis is correct?
- A VDRL titers are typically highest in secondary syphilis and may decline spontaneously in late latent disease ✓
- B Treponemal-specific antibodies (anti-Treponema pallidum IgG) usually decline and become undetectable in late latent syphilis
- C Non-treponemal antibody titers typically rise steadily from primary through tertiary syphilis
- D FTA-ABS becomes non-reactive after successful treatment, whereas VDRL remains reactive for life
Correct answer: A. VDRL titers are typically highest in secondary syphilis and may decline spontaneously in late latent disease
Explanation
Non-treponemal antibody titers peak during secondary syphilis and may decline spontaneously in late latent syphilis even without treatment. Treponemal-specific IgG antibodies usually persist for life regardless of treatment. FTA-ABS typically remains reactive for life after infection and is not used to monitor treatment response. VDRL titers, not treponemal antibodies, are used to monitor disease activity and treatment response.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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