HLA matching for allograft success is most important for which type of organ transplantation?

• A Cardiac transplantation
• B Hepatic transplantation
• C Corneal transplantation
• D Renal transplantation ✓

Explanation

Degree of HLA matching correlates strongly with long-term graft survival in renal transplantation; a 0-mismatch kidney has markedly improved 10-year survival compared to 6-antigen mismatch. Cardiac transplantation is time-limited by ischaemic time, making prospective HLA matching impractical. The liver is relatively HLA-tolerant due to its unique immunological properties. The cornea is immune-privileged due to avascular anterior stroma, making HLA matching less critical.

Reference: Ananthanarayan & Paniker's Textbook of Microbiology, 11th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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