Non-typhoidal Salmonella serotypes (S. Enteritidis, S. Typhimurium) cause invasive gastroenteritis by invading the intestinal epithelium. Which specific cell type in the Peyer patches is the primary portal of entry for Salmonella invasion?
- A Goblet cells
- B Enteroendocrine cells
- C M cells (microfold cells) ✓
- D Paneth cells
Correct answer: C. M cells (microfold cells)
Explanation
M cells (microfold cells) overlying Peyer patches are the primary portal of entry for Salmonella. These specialized epithelial cells sample luminal antigens and deliver them to underlying immune cells. Salmonella exploits this transcytosis pathway via Type III secretion system effectors (SipA, SopE) that trigger membrane ruffling and bacterial uptake. Goblet cells secrete mucus. Enteroendocrine cells produce hormones. Paneth cells secrete antimicrobial peptides.
Reference: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.