Uncomplicated cystitis in a young sexually active woman is most commonly caused by uropathogenic E. coli (UPEC). Which specific adhesin mediates binding to the Galalpha1-4Gal-containing glycolipids on uroepithelial cells, preventing washout during micturition?

• A P fimbriae (PapG adhesin) ✓
• B Type 1 fimbriae (FimH)
• C S fimbriae (SfaS)
• D Curli fibers

Explanation

P fimbriae (pyelonephritis-associated pili) terminate in the PapG adhesin, which binds specifically to Galalpha1-4Gal globoseries glycolipids on uroepithelium and kidney. This is strongly associated with pyelonephritis and ascending UTI. Type 1 fimbriae bind mannosylated uroplakins and cause cystitis but not via Galalpha1-4Gal. S fimbriae bind sialic acid. Curli are amyloid fibers involved in biofilm formation.

Reference: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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