Which vasculitis is characterised by granulomatous inflammation of the aorta and its major branches, predominantly affects women under 50 years, and shows skip lesions on histology?

• A Giant cell arteritis
• B Polyarteritis nodosa
• C Kawasaki disease
• D Takayasu arteritis ✓

Explanation

Takayasu arteritis is a granulomatous large-vessel vasculitis affecting the aorta and major branches, predominantly in women under 40–50 years, common in Asian populations. It causes limb claudication, absent pulses, BP differences between arms, and aortic regurgitation. Skip lesions are characteristic histologically. Giant cell arteritis also affects large vessels but occurs in patients >50 years and preferentially involves the external carotid branches (temporal artery). PAN is a medium-vessel vasculitis sparing the lungs.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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