Regarding the Chapel Hill Consensus Classification of vasculitides, ANCA-associated vasculitis (AAV) includes which three conditions?
- A Polyarteritis nodosa, GPA, and Takayasu arteritis
- B Granulomatosis with polyangiitis (GPA), Eosinophilic GPA (EGPA), and Microscopic polyangiitis (MPA) ✓
- C GPA, MPA, and IgA vasculitis
- D Cryoglobulinaemic vasculitis, EGPA, and GPA
Correct answer: B. Granulomatosis with polyangiitis (GPA), Eosinophilic GPA (EGPA), and Microscopic polyangiitis (MPA)
Explanation
Per the 2012 Revised International Chapel Hill Consensus Conference Nomenclature, ANCA-associated small vessel vasculitides comprise Granulomatosis with polyangiitis (formerly Wegener's), Eosinophilic GPA (formerly Churg-Strauss), and Microscopic polyangiitis. GPA is typically associated with PR3-ANCA (c-ANCA), MPA with MPO-ANCA (p-ANCA), and EGPA with MPO-ANCA (though it can be ANCA-negative). Polyarteritis nodosa is a medium-vessel vasculitis that is ANCA-negative.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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