A 5-year-old boy presents with palpable purpura over the buttocks and lower extremities, colicky abdominal pain, and hematuria. Renal biopsy shows mesangial IgA deposition. What is the most likely renal diagnosis?
- A Minimal change disease
- B Membranous nephropathy
- C IgA nephropathy ✓
- D Focal segmental glomerulosclerosis
Correct answer: C. IgA nephropathy
Explanation
Henoch-Schönlein purpura (IgA vasculitis) is an IgA-mediated small-vessel vasculitis. Renal involvement manifests as IgA nephropathy, identical to Berger disease, with mesangial IgA deposits. Membranous nephropathy, minimal change, and FSGS are not associated with this clinical picture of palpable purpura and abdominal pain.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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