A 44-year-old man presents with recurrent oral ulcers, genital ulcers, uveitis, and pathergy test positivity. Which HLA type is most strongly associated with this condition?
- A HLA-B51 ✓
- B HLA-B27
- C HLA-DR4
- D HLA-DQ2
Correct answer: A. HLA-B51
Explanation
Behçet's disease, characterised by oral ulcers, genital ulcers, uveitis, and skin lesions (with a positive pathergy test), is strongly associated with HLA-B51 (particularly the B*5101 subtype). The prevalence is highest along the ancient Silk Road (Turkey, Iran, Japan). HLA-B27 is associated with ankylosing spondylitis and reactive arthritis. HLA-DR4 is associated with RA and HLA-DQ2/DQ8 with coeliac disease.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.