Anti-Jo-1 antibody is characteristically associated with which clinical syndrome in inflammatory myopathy?
- A Amyopathic dermatomyositis with rapidly progressive ILD
- B Anti-synthetase syndrome: myositis, mechanic's hands, ILD, arthritis and Raynaud's ✓
- C Inclusion body myositis
- D Necrotizing autoimmune myopathy with HMG-CoA reductase antibodies
Correct answer: B. Anti-synthetase syndrome: myositis, mechanic's hands, ILD, arthritis and Raynaud's
Explanation
Anti-Jo-1 is the prototype anti-synthetase antibody (targeting histidyl-tRNA synthetase) and defines the anti-synthetase syndrome, comprising the pentad of inflammatory myopathy, interstitial lung disease, non-erosive arthritis, mechanic's hands (hyperkeratotic fissuring of lateral fingers), and Raynaud's phenomenon. ILD in anti-synthetase syndrome is often NSIP or OP pattern. Anti-MDA5 (anti-CADM-140) is associated with amyopathic dermatomyositis and rapidly progressive ILD. Anti-HMGCR antibodies define statin-associated necrotizing myopathy.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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