Anti-Jo-1 antibodies are associated with which specific constellation of findings in inflammatory myopathy?

• A Dermatomyositis with amyopathic presentation and lung involvement
• B Antisynthetase syndrome: myositis, interstitial lung disease, mechanic's hands, arthritis, Raynaud's ✓
• C Necrotizing autoimmune myopathy associated with statin exposure
• D Inclusion body myositis with distal and finger flexor weakness

Explanation

Anti-Jo-1 is an anti-aminoacyl tRNA synthetase antibody (anti-histidyl tRNA synthetase) and is the hallmark of antisynthetase syndrome, characterized by the pentad of inflammatory myopathy, interstitial lung disease (the dominant manifestation and cause of mortality), mechanic's hands (roughened fissured skin on radial fingers), inflammatory polyarthritis, and Raynaud's phenomenon. Anti-MDA5 antibodies are associated with amyopathic dermatomyositis and rapidly progressive ILD. Anti-SRP and anti-HMGCR antibodies are associated with necrotizing autoimmune myopathy.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

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Written and medically reviewed by the StethoPrep medical team.