Anti-topoisomerase I (anti-Scl-70) antibodies are most strongly associated with which subset of systemic sclerosis and its primary complication?
- A Limited cutaneous SSc; primary biliary cholangitis
- B Limited cutaneous SSc; pulmonary arterial hypertension
- C Diffuse cutaneous SSc; interstitial lung disease ✓
- D Diffuse cutaneous SSc; scleroderma renal crisis
Correct answer: C. Diffuse cutaneous SSc; interstitial lung disease
Explanation
Anti-Scl-70 (anti-topoisomerase I) antibodies are characteristically associated with diffuse cutaneous systemic sclerosis (dcSSc) and confer a high risk of interstitial lung disease (ILD), particularly non-specific interstitial pneumonia (NSIP). Anti-centromere antibodies are associated with limited cutaneous SSc (CREST) and pulmonary arterial hypertension. Anti-RNA polymerase III antibodies are associated with dcSSc and scleroderma renal crisis. These antibody-complication associations are high-yield for NEET-PG.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.