A 62-year-old man with 15 years of poorly controlled type 2 diabetes undergoes kidney biopsy during evaluation of proteinuria. Light microscopy shows nodular accumulations of PAS-positive mesangial matrix with laminated appearance, along with hyaline arteriolosclerosis of both afferent and efferent arterioles. These nodular lesions are known by which eponym?
- A Weichselbaum nodules
- B Kimmelstiel-Wilson nodules ✓
- C Aschoff nodules
- D Heberden nodes
Correct answer: B. Kimmelstiel-Wilson nodules
Explanation
Kimmelstiel-Wilson nodules are the pathognomonic acellular nodular glomerulosclerosis lesions of diabetic nephropathy, formed by expansion of the mesangial matrix, accompanied by hyaline arteriolosclerosis affecting both afferent and efferent arterioles, a combination unique to diabetes. Aschoff bodies occur in rheumatic myocarditis, Heberden nodes are osteoarthritic finger joint swellings, and Weichselbaum is not associated with any renal lesion, making these distractors easy to eliminate on anatomical grounds alone.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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