The KDIGO 2022 guidelines for CKD classify all stages of CKD using GFR category (G1–G5) and albuminuria category (A1–A3). The combination of G3bA3 denotes which risk category for adverse CKD outcomes?

• A Moderately increased risk
• B High risk
• C Moderately high risk
• D Very high risk ✓

Explanation

The KDIGO heat map assigns risk as green (low), yellow (moderately increased), orange (high), or red (very high). G3b (GFR 30–44 mL/min/1.73m²) with A3 (albuminuria ≥300 mg/g, i.e., macroalbuminuria) falls in the red/very high risk zone. This combination predicts rapid progression, cardiovascular events, and mortality. Management includes RAAS inhibition (ACE inhibitor or ARB), and in diabetic CKD, SGLT2 inhibitors and finerenone are added per FIDELIO/FIGARO trials to reduce progression.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.