A 25-year-old man develops acute onset of bilateral ophthalmoplegia, ataxia, and areflexia 2 weeks after a diarrheal illness. CSF shows albuminocytologic dissociation. The antibody most associated with this variant of GBS is directed against

• A GM1 ganglioside
• B Voltage-gated calcium channel
• C Myelin-associated glycoprotein (MAG)
• D GQ1b ganglioside ✓

Explanation

This describes Miller Fisher syndrome, a GBS variant characterized by ophthalmoplegia, ataxia, and areflexia. Anti-GQ1b IgG antibodies are present in over 90 percent of cases and are highly specific. GM1 antibodies are associated with classic GBS. MAG antibodies are seen in chronic demyelinating neuropathies. VGCC antibodies are found in Lambert-Eaton syndrome.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.