A 60-year-old man with a non-cardioembolic minor ischemic stroke (NIHSS 3) is started on dual antiplatelet therapy. According to the CHANCE and POINT trials, what is the recommended duration of DAPT before switching to single antiplatelet therapy?

• A 7 days
• B 12 months
• C 90 days
• D 21 days ✓

Explanation

Current guidelines recommend dual antiplatelet therapy (Aspirin plus Clopidogrel) for 21 days following a minor non-cardioembolic ischemic stroke or high-risk TIA, followed by single antiplatelet therapy. Extending DAPT beyond 21 days increases bleeding risk without significant additional benefit in stroke prevention.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

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Written and medically reviewed by the StethoPrep medical team.