A 50-year-old man presents with fever, confusion, and olfactory hallucinations over 5 days. MRI brain shows T2/FLAIR hyperintensity in the medial temporal lobes bilaterally. What is the most urgent and specific treatment?
- A Ampicillin
- B Amphotericin B
- C Acyclovir ✓
- D Doxycycline
Correct answer: C. Acyclovir
Explanation
Herpes Simplex Encephalitis affects the temporal lobes and limbic system, causing hallucinations and confusion. High-dose IV Acyclovir must be started immediately without waiting for PCR results, as delay increases mortality. Ampicillin covers Listeria, which affects the brainstem.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.