A 25-year-old man presents with acute onset of diplopia and difficulty walking 2 weeks after a flu-like illness. Examination reveals bilateral ophthalmoplegia, ataxia, and areflexia. Sensory examination is normal. What is the most specific antibody associated with this variant of GBS?

• A Anti-GM1 antibody
• B Anti-GQ1b antibody ✓
• C Anti-AQP4 antibody
• D Anti-MAG antibody

Explanation

This describes Miller Fisher Syndrome, a variant of GBS characterized by the triad of ophthalmoplegia, ataxia, and areflexia. Anti-GQ1b antibodies are highly specific and present in over 90% of cases. Anti-GM1 is associated with classic motor GBS.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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