A 22-year-old man presents with ascending paralysis, absent deep tendon reflexes, and albuminocytological dissociation on CSF analysis 2 weeks after a Campylobacter jejuni gastroenteritis. Nerve conduction studies show absent F-waves and reduced CMAP amplitudes with relatively preserved conduction velocities. This variant of GBS is:
- A Acute motor axonal neuropathy (AMAN) ✓
- B Acute inflammatory demyelinating polyneuropathy (AIDP)
- C Miller Fisher syndrome
- D Acute sensory neuropathy
Explanation
AMAN (acute motor axonal neuropathy) is the GBS variant strongly associated with Campylobacter jejuni infection and anti-GM1/GD1a ganglioside antibodies. Nerve conduction studies in AMAN show predominantly reduced CMAP amplitudes (axonal pattern affecting motor fibers only) with relatively preserved sensory nerve action potentials and normal/near-normal conduction velocities, distinguishing it from AIDP (where demyelination causes prolonged conduction velocities and absent F-waves with slowing). Miller Fisher syndrome features ophthalmoplegia, ataxia, and areflexia with anti-GQ1b antibodies.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.