In Guillain-Barré syndrome (GBS), the CSF finding of albuminocytological dissociation (raised protein with normal cell count) is typically seen from which day of illness onwards?
- A Day 1
- B Only after mechanical ventilation is commenced
- C Day 3–7 onwards, peaking at 4–6 weeks ✓
- D Day 14–21 exclusively
Correct answer: C. Day 3–7 onwards, peaking at 4–6 weeks
Explanation
In GBS, CSF protein elevation classically appears from approximately day 3–7 of illness and rises progressively, peaking at 4–6 weeks post-symptom onset. In the very early phase (first 48 hours), CSF may be completely normal, which does not exclude the diagnosis. Cell count is typically <10 cells/μL (albuminocytological dissociation, also called cytoalbuminous dissociation). Normal CSF in the first days of illness with classic clinical features should not delay IVIG or plasma exchange treatment.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.