Which statement about hepatitis E virus (HEV) infection in pregnancy is correct?
- A HEV is a DNA virus transmitted parenterally
- B Fulminant hepatitis is most common in the third trimester ✓
- C Fulminant hepatitis occurs most commonly in the first trimester
- D Vertical transmission to the fetus is rare
Correct answer: B. Fulminant hepatitis is most common in the third trimester
Explanation
Hepatitis E is an RNA virus transmitted fecal-orally. In pregnant women, particularly with genotypes 1 and 2, fulminant hepatitis occurs in 15-25% of cases, with the highest severity in the third trimester. Vertical transmission occurs in up to one-third of cases in the third trimester. Mortality in pregnant women can reach 15-25% in endemic regions, especially during outbreaks.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.