A 45-year-old man with Child-Pugh C cirrhosis develops acute-on-chronic liver failure (ACLF) precipitated by bacterial infection. Which scoring system is MOST validated for short-term mortality prediction in ACLF?
- A Child-Pugh score
- B MELD-Na score
- C CLIF Consortium ACLF score (CLIF-C ACLF score) ✓
- D King's College Criteria
Correct answer: C. CLIF Consortium ACLF score (CLIF-C ACLF score)
Explanation
The CLIF-C ACLF score was specifically developed and validated for ACLF in the CANONIC study and CLIF consortium data, and outperforms MELD and Child-Pugh for predicting 28-day and 90-day mortality in ACLF. It incorporates organ failure scores using the CLIF-C Organ Failure (OF) score. MELD-Na is validated for chronic liver disease and transplant listing but not specifically for ACLF trajectory. King's College Criteria are used for acute liver failure (ALF), not ACLF.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.