Kayser-Fleischer rings in Wilson's disease are best detected by:

• A Direct ophthalmoscopy
• B Visual acuity testing
• C Fundus fluorescein angiography
• D Slit-lamp examination ✓

Explanation

Kayser-Fleischer rings are golden-brown copper deposits in Descemet's membrane at the periphery of the cornea, best seen by slit-lamp examination performed by an ophthalmologist. They may be subtle and invisible to the naked eye, especially early. KF rings are present in nearly all patients with neuropsychiatric Wilson's disease but in only 50–60% of those with hepatic presentation. Their absence does not exclude Wilson's; serum ceruloplasmin and 24-hour urine copper remain essential diagnostically.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.