Which drug prevents NSAID-induced gastric ulcers by replacing inhibited protective prostaglandins, but its use is restricted by an abortifacient effect and dose-related diarrhea?
- A Sucralfate
- B Misoprostol ✓
- C Ranitidine
- D Bismuth subsalicylate
Correct answer: B. Misoprostol
Explanation
Misoprostol is a synthetic prostaglandin E1 analogue that restores gastric mucosal prostaglandin-mediated mucus and bicarbonate secretion suppressed by NSAIDs, and it reduces both gastric and duodenal ulcer incidence in chronic NSAID users. Its uterotonic activity can induce abortion, so it is absolutely contraindicated in pregnancy, and diarrhea limits adherence. Sucralfate forms a protective barrier but does not reliably prevent NSAID gastric ulcers, ranitidine is less effective than PPIs for prevention, and bismuth has no proven prophylactic role here.
Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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