Which cutaneous extraintestinal manifestation of inflammatory bowel disease characteristically does NOT parallel intestinal disease activity?
- A Erythema nodosum
- B Episcleritis
- C Pyoderma gangrenosum ✓
- D Aphthous stomatitis
Correct answer: C. Pyoderma gangrenosum
Explanation
Pyoderma gangrenosum runs an independent course and may appear or worsen even when the bowel disease is quiescent, and it may progress despite adequate control of colitis. Erythema nodosum, episcleritis, and aphthous ulcers typically flare and remit in parallel with intestinal activity, so treating the bowel disease usually improves them. This dissociation is why pyoderma gangrenosum often needs separate therapy such as systemic steroids or anti-TNF agents.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.