The SPRINT trial (2015) randomised hypertensive patients without diabetes to intensive (SBP target < 120 mmHg) versus standard (SBP < 140 mmHg) blood pressure control. The primary finding was:
- A Intensive control had no benefit over standard control for cardiovascular outcomes
- B Intensive control caused more strokes due to cerebral hypoperfusion
- C Intensive control significantly reduced fatal and non-fatal cardiovascular events and all-cause mortality ✓
- D Intensive control improved renal outcomes but worsened cardiovascular outcomes
Correct answer: C. Intensive control significantly reduced fatal and non-fatal cardiovascular events and all-cause mortality
Explanation
The SPRINT trial (NEJM 2015) demonstrated that intensive SBP control (< 120 mmHg) compared to standard control (< 140 mmHg) significantly reduced the primary composite of MI, ACS, stroke, HF, or cardiovascular death (25% relative risk reduction) and all-cause mortality (27% RRR) in non-diabetic adults with hypertension at increased CV risk. The trial was stopped early. This influenced the ACC/AHA 2017 guidelines updating BP targets.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.