An 62-year-old man has generalized lymphadenopathy with circulating medium-sized lymphoid cells having irregular clefted nuclei. Node biopsy shows a diffuse pattern with cells expressing CD5, CD19, FMC7, surface Ig strong positivity, and nuclear cyclin D1. Which translocation is characteristic?
- A t(14;18)(q32;q21)
- B t(11;14)(q13;q32) ✓
- C t(8;14)(q24;q32)
- D t(11;18)(q21;q21)
Correct answer: B. t(11;14)(q13;q32)
Explanation
CD5-positive mature A-cell lymphoma with cyclin D1 overexpression from juxtaposition of CCND1 to the IGH promoter by t(11;14) is mantle cell lymphoma; SOX11 supports diagnosis in cyclin-D1-negative cases. The distractor t(14;18) causes BCL2 overexpression in follicular lymphoma, which is CD10 and BCL6 positive but CD5 negative. t(8;14) dysregulates MYC in Burkitt lymphoma and t(11;18) defines MALT lymphoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.