A 61-year-old man presents with generalized lymphadenopathy and diarrhoea. Colonoscopy shows polypoid mucosal lesions. Flow cytometry of a node shows CD19+, CD5+ B cells that are CD23-negative. Which molecular abnormality is characteristic?
- A t(14;18) with BCL2 overexpression
- B t(11;14) with cyclin D1 overexpression ✓
- C t(8;14) with MYC overexpression
- D t(15;17) with PML-RARA fusion
Correct answer: B. t(11;14) with cyclin D1 overexpression
Explanation
Mantle cell lymphoma is a CD5-positive, CD23-negative mature B-cell neoplasm driven by t(11;14), which places the CCND1 gene under immunoglobulin heavy chain promoter control and causes cyclin D1 overexpression detectable by nuclear staining. Gastrointestinal polyposis is a classic presentation. t(14;18) defines follicular lymphoma, t(8;14) defines Burkitt lymphoma, and t(15;17) defines acute promyelocytic leukaemia.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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