According to the World Health Organization diagnostic criteria for polycythemia vera, which combination of findings is required for diagnosis in a patient with JAK2 V617F mutation?
- A Subnormal serum erythropoietin level
- B Hypercellular bone marrow with panmyelosis
- C Hemoglobin >16.5 g/dL in men ✓
- D Presence of endogenous erythroid colonies
Correct answer: C. Hemoglobin >16.5 g/dL in men
Explanation
The WHO criteria for PV require three major criteria or the first two major criteria plus one minor criterion. Major criteria are hemoglobin >16.5 g/dL in men, bone marrow biopsy showing panmyelosis, and JAK2 mutation. Since the stem specifies JAK2 V617F is present, the hemoglobin threshold is a required major criterion for diagnosis.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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