A 60-year-old woman presents with painless, generalized lymphadenopathy. Biopsy reveals a follicular pattern of small cleaved cells. Which cytogenetic abnormality is most characteristically associated with this lymphoma?
- A t(8;14)
- B t(14;18) ✓
- C t(11;14)
- D t(2;5)
Correct answer: B. t(14;18)
Explanation
Follicular lymphoma is characterized by t(14;18), which results in the overexpression of the BCL2 oncogene, inhibiting apoptosis. t(8;14) is seen in Burkitt lymphoma involving c-MYC. t(11;14) is seen in mantle cell lymphoma involving Cyclin D1. t(2;5) is seen in anaplastic large cell lymphoma involving ALK.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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