In Hodgkin lymphoma, which subtype is associated with LP (lymphocyte predominant) cells (popcorn cells), CD20 positive, CD15 negative, CD30 negative, and an indolent clinical course distinct from classical HL?

• A Nodular sclerosis Hodgkin lymphoma
• B Mixed cellularity Hodgkin lymphoma
• C Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) ✓
• D Lymphocyte-rich classical Hodgkin lymphoma

Explanation

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a distinct entity characterised by LP cells (formerly lacunar cells with multilobated nuclei resembling popcorn), which are CD20+, CD45+, BCL-6+ but CD15−, CD30−, unlike the Reed-Sternberg cells of classical HL (CD15+, CD30+, CD20−). NLPHL has an indolent behaviour, late relapses, and risk of transformation to diffuse large B-cell lymphoma. Treatment strategies differ from classical HL, including consideration of anti-CD20 (rituximab).

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.