The endocrinopathy that is most frequently the first manifestation of multiple endocrine neoplasia type 1 is:

• A Gastrinoma causing peptic ulcer disease
• B Primary hyperparathyroidism ✓
• C Prolactinoma
• D Insulinoma with fasting hypoglycaemia

Explanation

MEN1 comprises tumours of the parathyroid, pancreas, and anterior pituitary, with adrenocortical and neuroendocrine tumours also described. Primary hyperparathyroidism occurs in roughly 90 percent of gene carriers and typically appears in the second or third decade, making it both the commonest and the earliest lesion. Pancreatic endocrine tumours such as gastrinomas and insulinomas, and pituitary adenomas, usually declare themselves later in the course.

Reference: Williams Textbook of Endocrinology, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.