Which thyroid carcinoma type is characterized by amyloid stroma on histopathology and elevated serum calcitonin?

• A Medullary thyroid carcinoma ✓
• B Follicular thyroid carcinoma
• C Papillary thyroid carcinoma
• D Anaplastic thyroid carcinoma

Explanation

Medullary thyroid carcinoma arises from parafollicular A cells, which produce calcitonin. Deposition of calcitonin-derived amyloid is a characteristic histological feature. Papillary and follicular carcinomas derive from follicular cells and do not secrete calcitonin. Anaplastic carcinoma is undifferentiated and lacks calcitonin production.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.