Which endocrine tumour is the most common presenting manifestation of multiple endocrine neoplasia type 1?
- A Parathyroid hyperplasia ✓
- B Gastrinoma
- C Prolactinoma
- D Non-functioning adrenal adenoma
Correct answer: A. Parathyroid hyperplasia
Explanation
Primary hyperparathyroidism from multiglandular parathyroid hyperplasia occurs in about 90% of MEN1 patients and is usually the first manifestation, often appearing by the third decade. Gastrinomas and other pancreatic neuroendocrine tumours and pituitary adenomas follow in frequency. Hypercalcaemia in a young patient with a family history should therefore prompt screening for MEN1, caused by germline mutation of the MENIN tumour suppressor gene on chromosome 11q13.
Reference: Williams Textbook of Endocrinology, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.