A 30-year-old woman presents with low-grade fever, bilateral parotid enlargement, anterior uveitis and a new lower motor neuron type facial weakness. Chest radiograph shows bilateral hilar lymphadenopathy. What is the most likely diagnosis?
- A Sjogren syndrome
- B Mikulicz disease
- C Heerfordt syndrome ✓
- D Kimura disease
Correct answer: C. Heerfordt syndrome
Explanation
Heerfordt syndrome, or uveoparotid fever, is a presentation of sarcoidosis combining parotid enlargement, uveitis, fever and cranial nerve palsies, classically facial nerve palsy. Hilar lymphadenopathy supports sarcoidosis. Mikulicz disease refers to painless lacrimal and salivary enlargement without uveitis or nerve palsy, Sjogren syndrome features anti-Ro/La antibodies and sicca symptoms rather than uveitis, and Kimura disease presents with eosinophilia and subcutaneous masses.
Reference: Diseases of Ear, Nose and Throat (Dhingra), 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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