Histological examination of an actively progressing otosclerotic lesion would show which of the following?

• A Dense lamellar bone with osteoblastic rimming and sclerotic remodelling
• B Amyloid deposition in the spiral ligament
• C Caseating granulomas with Langhans giant cells
• D Highly vascular, cellular immature bone with osteoclasts and blue mantles of Manasse around vascular channels ✓

Explanation

The active phase, called otospongiosis, shows replacement of normal enchondral bone by highly vascular, cellular woven bone rich in osteocytes and osteoclasts. Vascular channels are surrounded by basophilic staining called the blue mantles of Manasse. Dense sclerotic lamellar bone describes the inactive healed phase, while granulomas and amyloid are unrelated to otosclerosis.

Reference: Cummings Otolaryngology: Head and Neck Surgery, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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