A 28-year-old with nasal polyps, chronic purulent sinusitis, and bronchiectasis is most likely to have which underlying condition?

• A Allergic rhinitis
• B Primary ciliary dyskinesia (Kartagener syndrome if with situs inversus) ✓
• C Aspirin-exacerbated respiratory disease (Samter's triad)
• D Granulomatosis with polyangiitis (Wegener's)

Explanation

The triad of nasal polyps, chronic sinusitis, and bronchiectasis in a young patient strongly suggests primary ciliary dyskinesia (PCD); when combined with situs inversus, it constitutes Kartagener syndrome. PCD causes impaired mucociliary clearance leading to recurrent respiratory infections and structural lung disease. Samter's triad is nasal polyps + asthma + aspirin sensitivity (no bronchiectasis). GPA causes saddle-nose and subglottic stenosis but typically presents with renal involvement and granulomatous necrotising lesions.

Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.