A 35-year-old man presents with recurrent unilateral nasal polyps, anosmia, and CT showing opacification of multiple sinuses. Histopathology of the polyp shows eosinophilic infiltrate with Charcot-Leyden crystals. The most likely diagnosis is:
- A Eosinophilic chronic rhinosinusitis with nasal polyps ✓
- B Inverted papilloma
- C Angiofibroma
- D Rhinoscleroma
Correct answer: A. Eosinophilic chronic rhinosinusitis with nasal polyps
Explanation
Eosinophilic infiltration with Charcot-Leyden crystals (breakdown products of eosinophil granules) in nasal polyp tissue is diagnostic of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). This is the most common form of sinonasal polyposis in adults, associated with asthma and NSAID sensitivity (Samter's triad). Inverted papilloma is typically unilateral without eosinophilia.
Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.