In auditory brainstem response (ABR) testing, Wave V has the largest amplitude and longest latency. In a child with auditory neuropathy spectrum disorder (ANSD), the ABR typically shows:

• A Normal ABR waveforms with absent otoacoustic emissions (OAEs)
• B Absent Wave I with preserved Waves III and V
• C Absent or grossly abnormal ABR waveforms with present OAEs and cochlear microphonic ✓
• D Prolonged Wave V latency only, with normal Wave I

Explanation

Auditory neuropathy spectrum disorder (ANSD) is characterized by dysfunction at the level of the inner hair cells, auditory nerve, or their synapse. The hallmark audiological profile is: absent or grossly disordered ABR (reflecting neural dyssynchrony) combined with present otoacoustic emissions (OAEs, indicating intact outer hair cell function) and presence of cochlear microphonics (CM, indicating functional inner ear receptor potential). This combination — present OAEs with absent ABR — is pathognomonic for ANSD and distinguishes it from conventional SNHL.

Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.