A patient undergoes surgical excision of a vestibular schwannoma. Histopathological examination of the tumor shows alternating areas of dense spindle cells with nuclear palisading and loose myxoid stroma. What specific histopathological feature is characterized by the dense spindle cell areas with nuclear palisading?
- A Psammoma bodies with whorls
- B Antoni B areas with microcysts
- C Antoni A areas with Verocay bodies ✓
- D Rosenthal fibers with eosinophilic cores
Correct answer: C. Antoni A areas with Verocay bodies
Explanation
Vestibular schwannomas classically show Antoni C areas, which are dense spindle cell regions with nuclear palisading that form Verocay bodies. Antoni B areas are the loose and myxoid stroma seen alternating with them. Psammoma bodies and whorls are characteristic of meningiomas. Rosenthal fibers and eosinophilic cores are seen in pilocytic astrocytomas and chronic gliosis, not schwannomas.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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