A 30-year-old woman has low grade fever, bilateral painless parotid enlargement, anterior uveitis, and a new right lower motor neuron facial palsy. Chest radiograph shows bilateral hilar lymphadenopathy and serum ACE levels are raised. Which underlying condition explains this constellation?
- A Sarcoidosis presenting as Heerfordt syndrome ✓
- B Sjogren syndrome
- C IgG4-related disease
- D Mumps orchitis-associated parotitis
Correct answer: A. Sarcoidosis presenting as Heerfordt syndrome
Explanation
Heerfordt syndrome, also called uveoparotid fever, is a presentation of sarcoidosis combining parotid gland enlargement, uveitis, fever and cranial nerve involvement, with facial palsy being the classic neurological deficit. Raised serum ACE and bilateral hilar lymphadenopathy support systemic sarcoidosis. Sjogren syndrome causes dry eyes and dry mouth without uveitis or facial palsy, IgG4-related disease does not produce uveitis with hilar adenopathy, and mumps causes acute tender parotitis in children without chronic granulomatous features.
Reference: Harrison's Principles of Internal Medicine, 20th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.