Histopathological examination of a surgically excised vestibular schwannoma shows densely cellular areas with spindle cells arranged in palisades around eosinophilic nuclear-free zones. These structures are known as:

• A Psammoma bodies in a meningothelial whorl
• B Rosettes in a neuroblastoma
• C Pseudorosettes around vessels in an ependymoma
• D Verocay bodies in an Antoni A pattern ✓

Explanation

Vestibular schwannomas show a biphasic pattern: compact Antoni A areas where elongated spindle cell nuclei palisade alternately around acellular eosinophilic zones forming Verocay bodies, and loose, myxoid Antoni B areas. Psammoma bodies with meningothelial whorls define meningioma, which is the differential diagnosis for a cerebellopontine angle mass. Homer Wright rosettes occur in neuroblastoma and medulloblastoma, and perivascular pseudorosettes are typical of ependymoma, neither of which arises from Schwann cells.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.