The enzyme primarily responsible for the destructive osteolytic property of cholesteatoma is:

• A Alkaline phosphatase
• B Collagenase (matrix metalloproteinase) ✓
• C Lysozyme
• D Hyaluronidase

Explanation

Cholesteatoma causes bone erosion through the production of matrix metalloproteinases (MMPs), particularly collagenases and gelatinases, released by fibroblasts and keratinocytes in the perimatrix. These enzymes degrade collagen in bone and promote osteoclast-mediated resorption. TNF-alpha and IL-1 also contribute by activating osteoclasts. This explains the progressive destruction of ossicles, tegmen, and canal wall.

Reference: Dhingra Diseases of Ear, Nose and Throat, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.