Which triad defines the classic form of hypohidrotic ectodermal dysplasia?
- A Hypohidrosis, cataract, sensorineural deafness
- B Hyperhidrosis, nail dystrophy, palmoplantar keratoderma
- C Hypohidrosis, hypotrichosis, hypodontia with peg-shaped teeth ✓
- D Hypotrichosis, leukoplakia, nail dystrophy
Correct answer: C. Hypohidrosis, hypotrichosis, hypodontia with peg-shaped teeth
Explanation
The classic triad of hypohidrotic ectodermal dysplasia is hypohidrosis, hypotrichosis and hypodontia with conical peg-shaped teeth; most cases are X-linked recessive due to EDA mutations, and affected boys have unexplained fever from heat intolerance. Option D describes the triad of dyskeratosis congenita, which also includes bone marrow failure later in life.
Reference: Fitzpatrick's Dermatology, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.